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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EZR
All Species:
4.55
Human Site:
S488
Identified Species:
11.11
UniProt:
P15311
Number Species:
9
Phosphosite Substitution
Charge Score:
0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P15311
NP_001104547.1
586
69413
S488
V
S
Y
H
V
Q
E
S
L
Q
D
E
G
A
E
Chimpanzee
Pan troglodytes
XP_522176
765
86955
E667
V
I
P
P
T
E
N
E
H
D
E
H
D
E
N
Rhesus Macaque
Macaca mulatta
XP_001093089
756
88442
S658
L
S
Y
H
V
Q
E
S
L
Q
D
E
G
A
E
Dog
Lupus familis
XP_541173
586
69404
N488
V
S
Y
H
V
Q
D
N
L
Q
E
E
G
T
E
Cat
Felis silvestris
Mouse
Mus musculus
P26040
586
69388
G488
V
N
Y
H
V
Q
E
G
L
Q
D
E
G
A
E
Rat
Rattus norvegicus
P31977
586
69372
G488
V
N
Y
H
V
Q
E
G
L
Q
D
E
G
A
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q9PU45
583
68536
E485
V
I
P
P
T
E
N
E
H
D
E
H
D
E
N
Frog
Xenopus laevis
NP_001087392
582
69042
H484
V
Y
E
P
Y
R
V
H
E
P
D
D
G
L
D
Zebra Danio
Brachydanio rerio
O57457
619
70690
N523
E
K
T
P
N
D
P
N
Q
R
R
S
R
H
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P46150
578
68123
E480
A
E
D
E
N
E
N
E
E
E
L
T
N
G
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58.4
76.8
97.2
N.A.
96.5
96.4
N.A.
N.A.
76.4
81.7
22.2
N.A.
57.8
N.A.
N.A.
N.A.
Protein Similarity:
100
68.5
77.3
98.9
N.A.
99.1
99.1
N.A.
N.A.
89.2
92.3
41.5
N.A.
75
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
93.3
73.3
N.A.
86.6
86.6
N.A.
N.A.
6.6
20
0
N.A.
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
20
100
93.3
N.A.
93.3
93.3
N.A.
N.A.
20
40
13.3
N.A.
20
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
0
0
0
0
0
0
0
0
0
40
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
10
0
0
10
10
0
0
20
50
10
20
0
20
% D
% Glu:
10
10
10
10
0
30
40
30
20
10
30
50
0
20
50
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
20
0
0
0
0
60
10
0
% G
% His:
0
0
0
50
0
0
0
10
20
0
0
20
0
10
0
% H
% Ile:
0
20
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
10
0
0
0
0
0
0
0
50
0
10
0
0
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
20
0
0
20
0
30
20
0
0
0
0
10
0
20
% N
% Pro:
0
0
20
40
0
0
10
0
0
10
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
50
0
0
10
50
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
10
0
0
0
10
10
0
10
0
10
% R
% Ser:
0
30
0
0
0
0
0
20
0
0
0
10
0
0
0
% S
% Thr:
0
0
10
0
20
0
0
0
0
0
0
10
0
10
0
% T
% Val:
70
0
0
0
50
0
10
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
10
50
0
10
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _